HIGHLY SENSITIVE AND RAPID EVALUATION OF PYRIDOSTIGMINE IMPURITY B IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY COUPLED WITH TANDEM MASS SPECTROMETER AFTER ADMINISTRATION OF PYRIDOSTIGMINE TO HEALTHY VOLUNTEERS IN A PHARMACOKINETIC STUDY
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چکیده
منابع مشابه
Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of donepezil in human plasma samples. Diphenhydramine was used as the internal standard. The collision-induced transition m/z 380 --> 91 was used to analyze donepezil in selected reaction monitoring mode. The signal intensity of the m/z 380 --> 91 transition was found to relate l...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2018
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2018.v11i6.25038